- Do you need a certain quest?
- Do you need a high amount of magic find, defense or damage?
- Do you need a group to maximize profit or is it soloable?
- How to get there, how random is the spawn (if any)?
- How do you deal with the monsters at that place?
- Are there situations where you cancel that run?
- Any tips on how to make the most out of that run?
- What is the loot quality, quantity and expected profit?
I am aware that there are multiple answers on this question depending on your gear progress and capabilities. That is why your answer should include those requirements.
This question is intended as a reference of community wiki style answers.
Before you downvote or close, because you think this question is too subjective or too broad, please just try to be pragmatic.