I am trying to develop a population pharmacokinetic model using Simbiology,

My settings are

Estimation method: Estimating mixed effects model with nlmefit

Error model is proportional

Method to approximate non-linear mixed effect model likelihood is FOCE.

The FOCE model fitting progress shows a loglikelihood of around -200 (that is good) till iteration of 3500 but after that suddenly the loglikelihood goes to around -900.

Then it keeps on proceeding, untill finally a error comes that the maximum iteration has been obtained. Now the final model has loglikelihood of around -900.

But initially till 3500 iteration, it had a loglikelihood of -200. So finally should i take loglikelihood as -200 or -900?

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