This is a weird one. For some reason, last night my mouse partially stopped working. Movement is fine, but the mouse buttons don't work. Mainly it's the left button, but occasionally the right click and scroll-wheel fail too.
Initially I thought it could be the mouse itself (the left button seemed to get a bit "soft" recently), but I tried another mouse and had the same issue. Both are USB wireless optical mice. The keyboard is working okay 95%, only problem is Alt+Tab doesn't seem to work. Both keys work fine independently.
At the time it happened I was using Chrome, I dragged to scrollbar to scroll and when I released the mouse it was still holding scrollbar.
I'm using Ubuntu 9.10, I upgraded weeks ago and everything was working fine so I don't think it's related to that. I also hadn't run any updates (I have now just in case something fixed it). But no luck.