I use the Microsoft Natural MultiMedia Keyboard 1.0A. The keyboard is not a wireless board.
The Escape button and the function keys have never worked. I am currently running on 10.10. On previous incarnations the keys never worked either. However a recent journey through all the Microsoft options in System > Preference > Keyboard > Layouts suggested that the Escape button could be functional. The current setting is Generic 105-key (Intl) PC. Can I find out whether the keys can be made to work or not?
Of the top buttons, nothing happens when I press My Documents; a small red cross appears at the top right of the screen when I press My Pictures and the Media, Mail and Web/Home buttons work just fine.